Striated Muscle as Implantation Site for Transplanted Pancreatic Islets
نویسندگان
چکیده
Islet transplantation is an attractive treatment for selected patients with brittle type 1 diabetes. In the clinical setting, intraportal transplantation predominates. However, due to extensive early islet cell death, the quantity of islets needed to restore glucose homeostasis requires in general a minimum of two donors. Moreover, the deterioration of islet function over time results in few insulin-independent patients after five-year followup. Specific obstacles to the success of islet transplantation include site-specific concerns for the liver such as the instant blood mediated inflammatory reaction, islet lipotoxicity, low oxygen tension, and poor revascularization, impediments that have led to the developing interest for alternative implantation sites over recent years. Within preclinical settings, several alternative sites have now been investigated and proven favorable in various aspects. Muscle is considered a very promising site and has physiologically properties and technical advantages that could make it optimal for islet transplantation.
منابع مشابه
Clinical and Experimental Pancreatic Islet Transplantation to Striated Muscle
OBJECTIVE Curing type 1 diabetes by transplanting pancreatic islets into the liver is associated with poor long-term outcome and graft failure at least partly due to inadequate graft revascularization. The aim of the current study was to evaluate striated muscle as a potential angiogenic site for islet transplantation. RESEARCH DESIGN AND METHODS The current study presents a new experimental ...
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Espes, D. 2016. Engraftment of Pancreatic Islets in Alternative Transplantation Sites and the Feasibility of in vivo Monitoring of Native and Transplanted Beta-Cell Mass. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1211. 88 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9551-0. Islet transplantation is a possible curative treatment for typ...
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متن کامل
Comparison of Four Pancreatic Islet Implantation Sites
Although the liver is the most common site for pancreatic islet transplantation, it is not optimal. We compared kidney, liver, muscle, and omentum as transplantation sites with regard to operative feasibility, and the efficiency of implantation and glycemic control. Islets from C57BL/6 mice were transplanted into diabetic syngeneic recipients. The mean operative time and mortality were measured...
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عنوان ژورنال:
دوره 2011 شماره
صفحات -
تاریخ انتشار 2011